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Anti-CD42b (GPlbα)
糖蛋白Ibα(GPIbα)也称为CD42b,是血小板上GPIb-V-IX复合物的成分。 GPIb-V-IX复合物结合von Willebrand因子,使血小板粘附和血小板栓塞在血管损伤部位形成。 这些抗CD42b单克隆抗体是在杂交瘤细胞中产生的,该杂交瘤细胞是从用野生型小鼠血小板免疫的BALB / cGPIbα基因敲除小鼠中分离出来的。
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抗GPIbα单克隆抗体的表征
![截屏2020-03-02下午4.50.15.png](https://static.wixstatic.com/media/be8f5b_58aa6c707bb346e89cb7d11ddbab19ff~mv2.png/v1/fill/w_87,h_30,al_c,q_85,usm_0.66_1.00_0.01,blur_2,enc_auto/%E6%88%AA%E5%B1%8F2020-03-02%E4%B8%8B%E5%8D%884_50_15.png)
Monoclonal antibodies were generated in GPIbα-/- mice (immunized with wild-type platelets). Subtype and binding to platelets were analyzed by flow cytometry using washed platelets pre-incubated with 5 μg/mL of monoclonal antibodies and then incubation with FITC-conjugated anti-mouse IgM, IgG, IgG1, IgG2a, IgG2b, and IgG3 secondary antibodies. M: mouse, P: pig
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